Clinical characteristics and antibody profiles of chronic hepatitis C patients: Relation to hepatitis C virus genotypes

✍ Scribed by Nobukazu Yuki; Norio Hayashi; Eiji Mita; Hideki Hagiwara; Masahide Oshita; Kazuyoshi Ohkawa; Kazuhiro Katayama; Akinori Kasahara; Hideyuki Fusamoto; Takenobu Kamada

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 671 KB
• Volume: 45
• Category: Article
• ISSN: 0146-6615
• DOI: 10.1002/jmv.1890450209

✦ Synopsis

Abstract

Genotyping of 179 consecutive Japanese chronic hepatitis C patients was carried out based on the variation in the hepatitis C virus (HCV) core gene. The results were correlated with clinical features and antibody responses toward specific HCV proteins deduced from the nucleotide sequence of genotype I/1 a. Genotypes II/1 b, III/2a, and IV/2b were identified in 138 (77%), 24 (13%), and 12 (7%) patients, respectively. Five patients had double infections. Genotype dependence was observed only for antibody response toward the NS4 (5–1–1) protein, which was infrequent in genotype III/2a patients (33%) compared with genotype II/1 b (81%; P < 0.01) and genotype IV/2b (75%; P < 0.05). Following interferon‐α therapy, sustained aminotransferase normalisation was achieved by 89% (eight of nine) patients without antibody to the 5–1–1 protein and 33% (17 of 51) with it (P < 0.01). These findings indicate that absence of antibody response to the 5–1–1 protein is frequent in genotype III/2a HCV carriers and may serve to predict responses to interferon therapy. © 1995 Wiley‐Liss, Inc.