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Clinical aspects of a phase I trial of 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a novel antivascular agent

โœ Scribed by Jameson, M B; Thompson, P I; Baguley, B C; Evans, B D; Harvey, V J; Porter, D J; McCrystal, M R; Small, M; Bellenger, K; Gumbrell, L


Book ID
109997600
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
122 KB
Volume
88
Category
Article
ISSN
0007-0920

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A new short synthesis of 5,6-dimethylxan
โœ Shangjin Yang; William A. Denny ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 217 KB

A new short synthesis of 5,6-dimethylxanthenone-4-acetic acid (ASA404) is developed. The key steps of the synthesis are dibromination of 3,4-dimethylbenzoic acid, followed by regioselective coupling with 2hydroxyphenylacetic acid and subsequent cyclodehydration.