✦ LIBER ✦

Clinical and subclinical organ-specific autoimmune manifestations in Type 1 (insulin-dependent) diabetic patients and their first-degree relatives

✍ Scribed by C. Betterle; F. Zanette; B. Pedini; F. Presotto; L. B. Rapp; C. M. Monciotti; F. Rigon

Publisher: Springer
Year: 1984
Tongue: English
Weight: 642 KB
Volume: 26
Category: Article
ISSN: 0012-186X
DOI: 10.1007/bf00262215

No coin nor oath required. For personal study only.

✦ Synopsis

Studying 239 Type 1 (insulin-dependent) diabetic patients and 144 of their first-degree relatives, we found a significant prevalence of autoimmune manifestations in both groups, compared with sex- and age-matched control subjects (p less than 0.001). In particular, in diabetic patients we found a high frequency of autoimmune thyroid disease and idiopathic Addison's disease and also a significant prevalence of thyroid (p less than 0.001), parietal cell (p less than 0.05) and adrenal antibodies (p less than 0.05). In the relatives a high frequency of thyroid disease, thyroid, parietal cell and adrenal antibodies and a significant prevalence of islet cell antibodies (p less than 0.05) were detected. In both groups functional glandular tests and gastric biopsies performed on the basis of autoantibody positivity revealed 13 examples of subclinical hypothyroidism, two cases of reduced adrenocortical reserve and five of atrophic gastritis. Autoantibody screening in diabetic patients and their relatives permitted the early diagnosis of the underlying endocrine disorders.

📜 SIMILAR VOLUMES

Abnormal lymphocyte subsets in Kuwaiti p

Abnormal lymphocyte subsets in Kuwaiti patients with type-1 insulin-dependent diabetes mellitus and their first-degree relatives

✍ Salim A. Kaaba; Saleh A. Al-Harbi 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 478 KB

Autoantibodies and genetic factors assoc

Autoantibodies and genetic factors associated with the development of Type 1 (insulin-dependent) diabetes mellitus in first degree relatives of diabetic patients

✍ C. Thivolet; B. Beaufrère; L. Geburher; P. Chatelain; J. Orgiazzi; R. François 📂 Article 📅 1991 🏛 Springer 🌐 English ⚖ 673 KB

Factors associated with diabetes onset were analysed for their predictive value in 708 first-degree relatives of Type 1 (insulin-dependent) diabetic patients including 374 parents and 308 siblings of Type i diabetic patients. Relatives were prospectively followed for 2 304 subject years with blood s

Islet cell and insulin autoantibodies in

Islet cell and insulin autoantibodies in organ-specific autoimmune patients. Their behaviour and predictive value for the development of Type 1 (insulin-dependent) diabetes mellitus. A 10-year follow-up study

✍ C. Betterle; F. Presotto; B. Pedini; L. Moro; R. S. Slack; F. Zanette; R. Zanche 📂 Article 📅 1987 🏛 Springer 🌐 English ⚖ 530 KB

To evaluate the behaviour and predictive value of islet cell and insulin autoantibodies in patients with organ-specific autoimmune diseases, we followed 21 non-diabetic subjects for a mean period of 84 +/- 27 months. Ten patients were persistently seropositive for complement-fixing islet cell antibo

The pattern of basal and stimulated insu

The pattern of basal and stimulated insulin responses to intravenous glucose in first degree relatives of Type 1 (insulin-dependent) diabetic children and unrelated adults aged 5 to 50 years

✍ C. P. Smith; A. J. K. Williams; J. M. Thomas; H. R. Archibald; V. D. Algar; G. F 📂 Article 📅 1988 🏛 Springer 🌐 English ⚖ 443 KB

The pattern of insulin secretion was studied in 107 normal individuals aged 5 to 50 years. Intravenous glucose tolerance tests were performed on 64 islet-cell antibody negative siblings of diabetic children and on 43 normal adults. Puberty was staged using Tanner's criteria and subjects were grouped