Clinical and radiological response of leptomeningeal melanoma after whole brain radiotherapy and ipilimumab
β Scribed by Bot, I.; Blank, C. U.; Brandsma, D.
- Book ID
- 118784363
- Publisher
- Springer
- Year
- 2012
- Tongue
- English
- Weight
- 494 KB
- Volume
- 259
- Category
- Article
- ISSN
- 0340-5354
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## Abstract ## BACKGROUND: The aim of this study was to assess the role of systemic treatment after wholeβbrain radiotherapy (WBRT) in immunohistochemically defined biological subsets of breast cancer patients with brain metastases. ## METHODS: The group of 420 consecutive breast cancer patients
Three patients with metastatic malignant melanoma, 2 of whom were males with primary lesion on the shoulder, and a female with primary lesion on the ankle, with Clark's level III-IV, completely responded to interferon-DTIC, but failed in the brain. Radiologically, all the lesions were peripheral in