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Clinical and pathologic findings in 52 consecutively autopsied cases with multiple myeloma

✍ Scribed by Kumi Oshima; Yoshinobu Kanda; Yasuhito Nannya; Makoto Kaneko; Tamae Hamaki; Miyuki Suguro; Rie Yamamoto; Aki Chizuka; Tomohiro Matsuyama; Naoki Takezako; Akiyoshi Miwa; Atsushi Togawa; Hihumi Niino; Michiyo Nasu; Kiyoshi Saito; Toyohiko Morita

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 29 KB
Volume: 67
Category: Article
ISSN: 0361-8609
DOI: 10.1002/ajh.1067

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✦ Synopsis

Abstract

We studied clinical features and pathologic findings in 52 consecutively autopsied patients with multiple myeloma in our center between 1979 and 1998. Distant extraosseous involvement was found in 33 patients (63.5%). Thirty‐one patients (59.6%) were proven to have infection at autopsy, among which pneumonia was most common site of infection. Amyloidosis was shown in 8 patients. Second malignancies were observed in 4 cases. The three major causes of death were hemorrhage, infection, and renal failure, which accounted for death in approximately 70% of the patients. Advances in the anticancer and antimicrobial chemotherapies might have decreased deaths due to myeloma itself or infection. Am. J. Hematol. 67:1–5, 2001. © 2001 Wiley‐Liss, Inc.

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