Clinical and Pathologic Characteristics of Patients With BRCA-Positive and BRCA-Negative Breast Cancer
β Scribed by Comen, E.A.; Robson, M.E.
- Book ID
- 123094420
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 69 KB
- Volume
- 20
- Category
- Article
- ISSN
- 1043-321X
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Approximately 2% to 5% of all breast cancers are hereditary, meaning that the cancer predisposition is carried as a monogenic trait. Several highly penetrant breast cancer predisposing genes have been identified. These discoveries will permit a refined description of breast cancer occurring as part
## Abstract ## BACKGROUND BRCA1 and BRCA2 alterations are associated with an increased risk of developing breast carcinoma. The authors hypothesized that the progression of breast neoplasia may differ between patients with hereditary disease and patients with nonhereditary disease and that this di