𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Clinical and laboratory observations in a lymphoma-prone family

✍ Scribed by Jeffrey W. Clark; Margaret A. Tucker; Mark H. Greene

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
540 KB
Volume
60
Category
Article
ISSN
0008-543X

No coin nor oath required. For personal study only.

✦ Synopsis

Three sisters developed non-Hodgkin's lymphoma (NHL). Thirteen maternal relatives had adenocarcinomas of various types, predominantly breast and large bowel. Detailed laboratory assessment of this family revealed a variety of immunologic abnormalities. Two lymphoma patients had elevated anti-early antigens (EA) Epstein-Barr virus (EBV) titers. One of the two also had a markedly elevated anti-viral capsid antigen (VCA) EBV titer. The two lymphoma patients were human leukocyte antigen (HLA)-identical, but two unaffected siblings shared the same HLA haplotypes. One of the lymphoma patients and four unaffected family members were anergic; and three unaffected family members had a decreased percentage of T-cells. These data suggest that a subtle disturbance in cellular immune functions may play a causal role in some familial aggregations of malignant lymphoma.

πŸ“œ SIMILAR VOLUMES

Adrenocortical carcinoma : Clinical and
Adrenocortical carcinoma : Clinical and laboratory observations
✍ Bernardo Leo Wajchenberg; Maria A. Albergaria Pereira; Berenice B. Medonca; Ana πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 496 KB

## BACKGROUND. The clinical features and natural history of adrenocortical carcinoma are highly dependent on the type of center reporting their experience. Observations from oncology services suggest a high incidence of nonfunctioning tumors, whereas reports from endocrine clinics emphasize excess

Familial eosinophilia: Clinical and labo
Familial eosinophilia: Clinical and laboratory results on a U.S. Kindred
✍ Lin, Albert Y.; Nutman, Thomas B.; Kaslow, David; Mulvihill, John J.; Fontaine, πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 69 KB

We describe a five-generation kindred with familial eosinophilia (FE; MIM131400), characterized by the occurrence of sustained eosinophilia of unidentifiable cause in multiple relatives. The inheritance pattern is consistent with an autosomal dominant pattern. Among 52 related subjects studied, 19 w

A novel type of deletion in the CDKN2A g
A novel type of deletion in the CDKN2A gene identified in a melanoma-prone family
✍ Stian Knappskog; JΓΌrgen Geisler; Thomas Arnesen; Johan R. Lillehaug; Per E. LΓΈnn πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 297 KB

## Abstract Linkage to the __CDKN2A__ locus has been demonstrated in ∼50% of families with hereditary malignant melanoma but only a subgroup of these harbor identified mutations. We here report a Norwegian melanoma‐prone family with a novel large germline deletion removing 13707 bps of the __CDKN2A