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Clinical and Immunomodulatory Effects of Celecoxib Plus Interferon-Alpha in Metastatic Renal Cell Carcinoma Patients with COX-2 Tumor Immunostaining

โœ Scribed by Anita Schwandt; Jorge A. Garcia; Paul Elson; Jeanie Wyckhouse; James H. Finke; Joanna Ireland; Pierre Triozzi; Ming Zhou; Robert Dreicer; Brian I. Rini


Publisher
Springer
Year
2011
Tongue
English
Weight
189 KB
Volume
31
Category
Article
ISSN
0271-9142

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## Abstract ## BACKGROUND Cyclooxygenaseโ€2 (COXโ€2) plays a major role in the development of cancer through numerous mechanisms. COXโ€2 is expressed in the majority of renal cell carcinoma (RCC) tumors and correlates with stage, grade, and microvessel density. Based on potential additive or synergis