✦ LIBER ✦

Clinical and histologic features of level 2 cutaneous malignant melanoma associated with metastasis

✍ Scribed by Helen M. Shaw; William H. McCarthy; Richard A. Scolyer

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 59 KB
Volume: 95
Category: Article
ISSN: 0008-543X
DOI: 10.1002/cncr.10701

No coin nor oath required. For personal study only.

✦ Synopsis

W e are grateful for the results from Dr. Rodrı ´guez et al. supporting our previous article. 1 We agree with their conclusion that a combination assay of CYFRA 21-1 with carcinoembryonic antigen (CEA) and CA 15-3 is very useful for breast carcinoma, since the epitope of CYFRA 21-1 is a polypeptide whereas those of CEA and CA 15-3 are glycoproteins. We are particularly interested in the prognostic value of CYFRA 21-1 for disease recurrence after surgery. We now routinely measure CYFRA 21-1 for our patients with breast carcinoma prior to operation and at serial times after operation. Some patients with abnormal serum CYFRA 21-1 titers have maintained elevated levels of the marker after curative resection. These patients may have high risk of the disease relapse. The coming data from Dr. Rodrı ´guez et al. will contribute to a followup system for patients with breast carcinoma.

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