A new system for catalytic enantioselect
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E.J Corey; Raman K Bakshi
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Article
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1990
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Elsevier Science
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French
β 277 KB
The reduction of a variety of achiral ketones with catecholborane as stoichiometric reductant and 0.1 equiv of oxaxaborolidine 2 as catalyst in toluene at -78'C proceeds in > 95% yield and with enantioselectivities in the range 30: 1 to 9: 1, depending on substrate. This reduction procedure is espec