Cleistanone: A Triterpenoid from Cleistanthus indochinensis with a New Carbon Skeleton

✍ Scribed by Van Trinh Thi Thanh; Van Cuong Pham; Hung Huy Nguyen; Huong Doan Thi Mai; Hang Nguyen Thi Minh; Van Hung Nguyen; Marc Litaudon; Françoise Guéritte; Van Minh Chau

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 202 KB
• Volume: 2011
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/ejoc.201100505

✦ Synopsis

Abstract

Cleistanone (1) was isolated from the leaves of Cleistanthus indochinensis and features a new type of triterpenoid carbon skeleton. Its structure was confirmed by X‐ray diffraction analysis. A plausible biosynthetic pathway was proposed for 1 and is thought to proceed through a Wagner–Meerwein rearrangement. Cleistanone (1) was found to show cytotoxic activity against human oral epidermoid carcinoma KB cells.