Cleavage reactions of some steroidal epoxides
β Scribed by G.A. Morrison; J.B. Wilkinson
- Publisher
- Elsevier Science
- Year
- 1975
- Tongue
- French
- Weight
- 224 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
Triphenylphosphine -iodine complex was found to be an effective reagent for deoxygenation of trisubstituted steroidal epoxides. The mechanism of the reaction is proposed.
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The ethylene ketal of 5,6a-epoxycholestan-3-one is converted to a ketalised A~-6ct-01 on treatment with n-BuLi. However, the corresponding 6 epoxide undergoes opening of the ketal ring in the same reaction. Methyl-and n-butyl-