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Cleavage of MAGI-1, a tight junction PDZ protein, by caspases is an important step for cell-cell detachment in apoptosis

✍ Scribed by Uroš Gregorc; Saška Ivanova; Miranda Thomas; Ernesto Guccione; Britt Glaunsinger; Ron Javier; Vito Turk; Lawrence Banks; Boris Turk

Book ID
106349396
Publisher
Springer
Year
2006
Tongue
English
Weight
665 KB
Volume
12
Category
Article
ISSN
1360-8185

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## Abstract Presenilins (PSs) are mutated in a majority of familial Alzheimer disease (FAD) cases. Mutated PSs may cause FAD by a number of pro‐apoptotic mechanisms, or by regulating γ‐secretase activity, a protease involved in β‐amyloid precursor protein processing to the neurotoxic β‐amyloid pept