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Cleavage of eukaryotic initiation factor eIF5B by enterovirus 3C proteases

โœ Scribed by Sylvain de Breyne; Jennifer M. Bonderoff; Konstantin M. Chumakov; Richard E. Lloyd; Christopher U.T. Hellen


Book ID
113947543
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
518 KB
Volume
378
Category
Article
ISSN
0042-6822

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## Abstract Enterovirus (EV) infection has been shown to cause a marked shutoff of host protein synthesis, an event mainly achieved through the cleavages of eukaryotic translation initiation factors eIF4GI and eIF4GII that are mediated by viral 2A protease (2A^pro^). Using fluorescence resonance en