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Cleavage of DNA by iron bleomycin at large ratios of DNA to drug

✍ Scribed by W.E. Antholine; P. Fullmer; D. Petering

Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
87 KB
Volume
36
Category
Article
ISSN
0162-0134

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The sequence specificity of bleomycin A5 and of its light-activated cobalt complex were compared by examining the relative cleavage of each strand of two DNA fragments by either species. Significant differences between the two metallobleomycins were observed. The iron-bleomycin (Fe-BLM) complex clea