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Cleavage of cartilage oligomeric matrix protein (thrombospondin-5) by matrix metalloproteinases and a disintegrin and metalloproteinase with thrombospondin motifs

✍ Scribed by Sally C. Dickinson; Mireille N. Vankemmelbeke; David J. Buttle; Krisztina Rosenberg; Dick Heinegård; Anthony P. Hollander

Book ID
117640306
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
446 KB
Volume
22
Category
Article
ISSN
0945-053X

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Objective. To determine whether matrix metalloproteinases (MMPs) degrade cartilage oligomeric matrix protein (COMP) to produce fragments similar to those found in synovial fluid (SF) from patients with arthritis. Methods. COMP fragments were generated in vitro by treating (a) bovine articular carti