Clays as a Host Matrix in the Synthesis of Organic Macrocycles

✍ Scribed by Vasilios Georgakilas; Dimitrios Gournis; Athanasios B. Bourlinos; Michael A. Karakassides; Dimitrios Petridis

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 152 KB
• Volume: 9
• Category: Article
• ISSN: 0947-6539
• DOI: 10.1002/chem.200204555

✦ Synopsis

Abstract

A new approach for the synthesis of amide macrocycles, based on the use of organo‐clay derivatives as controlling template, is proposed as an alternative to the rotaxane method. Dications of p‐xylylene diamine inserted in the clay interlayer space act as molding pillars around which neutral diamine molecules are erected via hydrogen bonding and π–π interactions to form supramolecular arrays. Condensation of diamines in the supramolecular arrays with diacetyl dichlorides yields various tetramide macrocycles in good yields. Shape, aromaticity and dimensions of the reactants are factors affecting the condensation reaction.