## Abstract Human colon cancer cell lines express epidermal growth factor (EGF) mRNA, secrete EGF and may respond to it __via__ the cell‐surface EGF receptor (EGFR). Expression of these molecules in human colon and colon tumor, however, is not clear. Reverse transcription‐polymerase chain reaction
Claudin-2 expression increases tumorigenicity of colon cancer cells: role of epidermal growth factor receptor activation
✍ Scribed by Dhawan, P; Ahmad, R; Chaturvedi, R; Smith, J J; Midha, R; Mittal, M K; Krishnan, M; Chen, X; Eschrich, S; Yeatman, T J
- Book ID
- 109972895
- Publisher
- Nature Publishing Group
- Year
- 2011
- Tongue
- English
- Weight
- 955 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0950-9232
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## Abstract Human colon cancer cells produce and secrete a variety of polypeptide growth factors. The functional role of these growth factors, however, is poorly understood. Though the secretion of epidermal growth factor (EGF)‐like activity and EGF‐related molecules by human colon cancer cells in
Human colon cancer (Moser) cells produce and secrete epidermal growth factor (EGF) and respond to EGF via an autocrine/paracrine mode through the cell surface EGF receptor (EGFR). In this report we show that EGF promotes the malignant behavior of the Moser cells in vitro in terms of growth in soft a
Lung cancer tissues from 68 patients were examined for epidermal growth factor (EGF) receptor levels and EGF receptor gene copy numbers. Histologic cell types of these lung cancer tissues included squamous-cell carcinoma (n = 30), adenocarcinoma (n = 28), large-cell carcinoma (n = 4), and small-cell