Clathrate hydrates are poor models of biomolecule hydration

✍ Scribed by Leigh Ann Lipscomb; Fang Xiao Zhou; Loren Dean Williams

• Publisher: Wiley (John Wiley & Sons)
• Year: 1998
• Tongue: English
• Weight: 419 KB
• Volume: 38
• Category: Article
• ISSN: 0006-3525
• DOI: 10.1002/(sici)1097-0282(199602)38:2<177::aid-bip4>3.0.co;2-s

✦ Synopsis

Clathrate Hydrates Are Poor Models of Biomolecule Hydration Cluthratc hydrates .fi)rm the hasis of u gencrul model of biomolecide hydrution. In cluihrutc) hydrate crystul .structrirc~~s, the size qf f'hydrogcm-bonded watc7r rings is Iiigkdy construined to,five rnernhers. Thc cluthrute h j d r u t r modd predicts that the size of wuter ring.s neur hiomolecule sirrfuccs is sirnilur!,~ construined to j i v e members. This report dcxrihes u test of'this modtd o/ hiomol~.c.iilr hjdrution. U'e have demonstrated thut,fivcJ-memhered water rings urc not u generul jiwtiire o/protc.in or nicckic ucid hydration. The cluthrute hydrute model upprurs to he inuppropriutci.fiv soliib1tJ hiornol~~ciile~s. 0 1996 John Wiley & Sons, Inc.