Classifying G protein-coupled receptors and nuclear receptors on the basis of protein power spectrum from fast Fourier transform

Effects of N- and C-terminal addition of

Effects of N- and C-terminal addition of oligolysines or native loop residues on the biophysical properties of transmembrane domain peptides from a G-protein coupled receptor

✍ Patricia Cano-Sanchez; Beatrice Severino; V. V. Sureshbabu; Joe Russo; Tatsuya I 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 452 KB

## Abstract Transmembrane domains (TMDs) of G‐protein coupled receptors (GPCRs) have very low water solubility and often aggregate during purification and biophysical investigations. To circumvent this problem many laboratories add oligolysines to the __N__‐ and __C__‐termini of peptides that corre