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Classification of Water Molecules in Protein Binding Sites

✍ Scribed by Barillari, Caterina; Taylor, Justine; Viner, Russell; Essex, Jonathan W.

Book ID
120380322
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
422 KB
Volume
129
Category
Article
ISSN
0002-7863

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## Abstract Deregulation of protein kinases is associated with numerous diseases, making them important targets for drug discovery. The majority of drugs target the catalytic site of these proteins, but due to the high level of similarity within the ATP binding sites of protein kinases, it is often