Classification of rheumatoid arthritis: The importance of including data from the siblings
โ Scribed by Dr. D. J. Walker; A. M. Stephenson; I. D. Griffiths; D. F. Roberts; D. C. Rao
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 272 KB
- Volume
- 4
- Category
- Article
- ISSN
- 0741-0395
No coin nor oath required. For personal study only.
โฆ Synopsis
A discriminant analysis has been applied to physical and laboratory data on a series of 37 patients with rheumatoid arthritis (RA). Good discrimination was found between RA when it was associated with organ-specific autoimmune phenomena and when it was not. When data from other members of the families was included there was consistently better discrimination than when using data from the patients alone. The results suggest that future studies of classification of variable diseases should include study of relatives.
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Our understanding of the immunopathogenesis of rheumatoid arthritis (RA) has undergone a major revolution if we compare the concepts propounded 30 years ago with those proposed today. Synovitis is no longer conceived as an antibody-mediated process involving rheumatoid factors and immune complexes,
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