Classification of renal cell carcinoma : Workgroup No. 1

✍ Scribed by Stephan Störkel; John N. Eble; K. Adlakha; Mahul Amin; Michael L. Blute; David G. Bostwick; M. Darson; Brett Delahunt; K. Iczkowski

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 40 KB
• Volume: 80
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/(sici)1097-0142(19970901)80:5<987::aid-cncr24>3.0.co;2-r

✦ Synopsis

I n developing this proposal, the authors applied these principles:

1. The classification must be based on morphology yet be in line with the genetic facts as they are presently understood, and in line with the evolution of the neoplasms. 2. The terms should be simple, unambiguous, and reflect a salient morphologic feature of the neoplasm. 3. The terms should be consistent with historic usage when possible, but when the meaning has changed significantly, they should be replaced with a new term. 4. A term is not a description and cannot encompass all of the morphologic variations of a neoplasm. The proposed classifications follows.

Benign Neoplasms

1. Papillary adenoma is the most common neoplasm of the renal tubular epithelium and is a frequent incidental finding in adult kidneys. Most are õ3 mm. Lesions õ5 mm should be considered papillary adenoma. Their microscopic morphology resembles low grade papillary renal cell carcinoma to the extent that there are

no reliable cytologic criteria to distinguish individual examples from small carcinoma. That they are benign is inferred from their Presented at ''Diagnosis and Prognosis of Renal high frequency compared with the frequency of progressive papil-Cell Carcinoma: 1997 Workshop,'' Rochester, lary carcinoma. Their known genetic abnormalities (typically 0Y,