Classical swine fever virus down-regulates endothelial connexin 43 gap junctions

Connexin43, the major gap junction prote

Connexin43, the major gap junction protein of astrocytes, is down-regulated in inflamed white matter in an animal model of multiple sclerosis

✍ Elimor Brand-Schieber; Peter Werner; Dumitru A. Iacobas; Sanda Iacobas; Michelle 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 885 KB

Both multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), its animal model, involve inflammatory attack on central nervous system (CNS) white matter, leading to demyelination and axonal damage. Changes in astrocytic morphology and function are also prominent features of MS an