Claisen Condensation of N-Methylpyrrolidinone and α-Chloronicotinic esters

✍ Scribed by Thomas Kaminski; Gilbert Kirsch

• Book ID: 102340273
• Publisher: Journal of Heterocyclic Chemistry
• Year: 2008
• Tongue: English
• Weight: 436 KB
• Volume: 45
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570450128

✦ Synopsis

Abstract

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Reaction between α‐halo‐nicotinic esters and a nucleophilic source such as the N‐methylpyrrolidin‐2‐one (NMP) gave unexpected results. The presence of the halide on the pyridine gave a very interesting migration reaction. Extension to 6‐methylnicotinic ester derivatives lead to an unexpected carbanion condensation.