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Cladribine inhibits cytokine secretion by T cells independently of deoxycytidine kinase activity

✍ Scribed by Bruno Laugel; Frédéric Borlat; Laurent Galibert; Alain Vicari; Robert Weissert; Yolande Chvatchko; Denis Bruniquel

Book ID
113730906
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
980 KB
Volume
240-241
Category
Article
ISSN
0165-5728

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## Abstract ## Objective Chronic T cell activation is central to the etiology of rheumatoid arthritis (RA), an inflammatory autoimmune disease that leads to severe focal bone erosions and generalized systemic osteoporosis. Previous studies have shown novel cytokine‐like activities in medium contai