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Cladribine combined with cyclophosphamide and mitoxantrone as front-line therapy in chronic lymphocytic leukemia

✍ Scribed by Robak, T; Błoński, J Z; Kasznicki, M; Góra-Tybor, J; Dwilewicz-Trojaczek, J; Boguradzki, P; Konopka, L; Ceglarek, B; Sułek, J; Kuliczkowski, K


Book ID
110054977
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
121 KB
Volume
15
Category
Article
ISSN
0887-6924

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## Abstract ## BACKGROUND One of the mechanisms of action of cladribine is the inhibition of DNA repair of damage caused by radiation, alkylating agents, or other drugs. To determine its antitumor activity in combination with cyclophosphamide, we initiated a Phase II trial of the two agents in pat