Ciwujianosides D1 and C1: Powerful inhibitors of histamine release induced by anti-immunoglobulin E from rat peritoneal mast cells

✍ Scribed by Akemi Umeyama; Noboru Shoji; Masao Takei; Koichi Endo; Shigenobu Arihara

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 190 KB
• Volume: 81
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600810714

✦ Synopsis

In rat peritoneal mast cells induced by anti-immunoglobulin E, ciwujianosides D1 (1) and C1 (2) from Acanthopanax senticosus (ciwujia) strongly inhibited histamine release in a concentration-dependent manner. The inhibitory effect of 1 was approximately 6800 times stronger than that of disodium cromoglycate.