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Citrulline-Argininosuccinate-Arginine Cycle Coupled to Ca2+-Signaling in Rat Pancreatic β-Cells

✍ Scribed by Masanori Nakata; Toshihiko Yada; Shiro Nakagawa; Keiko Kobayashi; Ikuro Maruyama

Book ID
115580454
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
398 KB
Volume
235
Category
Article
ISSN
0006-291X

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Using rat [3-cells we present evidence that Sr 2+ and Ba 2+, like Ca 2+, support depolarization-induced increases in membrane capacitance which reflect insulin granule exocytosis. Even with identical total charge entry, Sr 2+ and Ba 2+ are 3-5 and 20-fold less effective than Ca 2+ in supporting rele