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Cisplatin + lonidamine effective in pretreated ovarian cancer

Book ID
120875448
Publisher
Adis International Limited (now part of Wolters Kluwer Health)
Year
1997
Weight
149 KB
Volume
&NA;
Category
Article
ISSN
1173-8324

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Enhancement of cisplatin activity by lon
Enhancement of cisplatin activity by lonidamine in human ovarian cancer cells
โœ Rosella Silvestrini; Nadia Zaffaroni; Raffaella Villa; Linda Orlandi; Aurora Cos ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 524 KB

The ability of lonidamine, an energolytic derivative of indazolecarboxylic acid, to modulate the cytotoxicity of cisplatin was investigated in human ovarian-cancer cell lines sensitive (A2780) or with experimentally induced resistance (A2780/cp8) to the alkylating agent. A 24-hr post-incubation with