Cisplatin-loaded Au–Au2S nanoparticles for potential cancer therapy: Cytotoxicity, in vitro carcinogenicity, and cellular uptake
✍ Scribed by Lei Ren; Xiao-Li Huang; Bin Zhang; Li-Ping Sun; Qi-Qing Zhang; Mei-Chee Tan; Gan-Moog Chow
- Book ID
- 102294169
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 313 KB
- Volume
- 85A
- Category
- Article
- ISSN
- 1549-3296
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✦ Synopsis
Abstract
Cisplatin is one of the most effective cytotoxic agents against cancers. Its usage, however, is limited because of severe resistance and systemic toxicity. A formulation of cisplatin‐loaded Au–Au~2~S nanoparticles (NPs) with near‐IR (NIR) sensitivity is reported to partly overcome this limitation in this paper. NIR sensitive Au–Au~2~S NPs were successfully synthesized by the reduction of tetrachloroauric acid (HAuCl~4~) using sodium sulfide (Na~2~S), and cisplatin was loaded onto Au–Au~2~S NPs via a MUA (11‐mercaptoundecanoic acid) layer. To further investigate the biological safety of cisplatin‐loaded Au–Au~2~S NPs, three different cell lines were used to investigate the acute cytotoxicity and the long‐term potential carcinogenicity in vitro. Cisplatin‐loaded Au–Au~2~S NPs were also tested for limited hemocompatibility in vitro. Our in vitro short and long‐term data provided preliminary evidence suggesting that cisplatin‐loaded Au–Au~2~S NPs with NIR sensitivity are nontoxic below the maximum recommended dosage. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008