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Cisplatin-induced nephrotoxicity is associated with oxidative stress, redox state unbalance, impairment of energetic metabolism and apoptosis in rat kidney mitochondria

✍ Scribed by N. A. G. Santos; C. S. Catão; N. M. Martins; C. Curti; M. L. P. Bianchi; A. C. Santos

Publisher: Springer-Verlag
Year: 2007
Tongue: English
Weight: 484 KB
Volume: 81
Category: Article
ISSN: 0340-5761
DOI: 10.1007/s00204-006-0173-2

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## Abstract Cisplatin is a potent and widely used chemotherapeutic agent. Nephrotoxicity induced by this drug has been well documented. However, very little information is available on cisplatin‐induced hepatotoxicity and its underlying mechanism remains unclear. High doses of cisplatin have been k