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Cisplatin-induced downregulation of miR-199a-5p increases drug resistance by activating autophagy in HCC cell

✍ Scribed by Ning Xu; Jianjun Zhang; Conghuan Shen; Yi Luo; Lei Xia; Feng Xue; Qiang Xia

Book ID: 116303617
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 707 KB
Volume: 423
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2012.06.048

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## Abstract Because solid growing tumors often show hypoxia and pronounced extracellular acidosis, the aim of this study was to analyze the impact of an acidotic environment on the activity of the p‐glycoprotein (pGP) and on the cellular content and cytotoxicity of the chemotherapeutic drug daunoru