CIS-diamminedichloroplatinum(II) inhibit
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Kazuto Nishio; Yasuhiro Fujiwara; Yuki Miyahara; Yuichiro Takeda; Tatsuo Ohira;
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Article
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1993
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John Wiley and Sons
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French
β 914 KB
cis-Diamminedichloroplatinum(ll) (CDDP) induced G2-phase arrest in PC-9 human cancer cells. To elucidate how CDDP acts on cell-cycle regulation, we analyzed the effect of CDDP on cell-cycle regulators such as protein kinase. p34cdc2 protein kinase activity was maximum in G2 phase and decreased after