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Cis-diamminedichloroplatinum (II): Second line induction chemotherapy in advanced ovarian adenocarcinoma

✍ Scribed by M. Steven Piver; Joseph J. Barlow; Shashikant B. Lele; John H. Malfetano; Mary Eileen McPhee

Publisher: John Wiley and Sons
Year: 1983
Tongue: English
Weight: 236 KB
Volume: 24
Category: Article
ISSN: 0022-4790
DOI: 10.1002/jso.2930240418

No coin nor oath required. For personal study only.

✦ Synopsis

Twenty-one evaluable patients received second-line chemotherapy for recurrent ovarian adenocarcinoma with induction Cisplatin given weekly followed by monthly combination chemotherapy. Forty-two percent of the patients responded to induction weekly Cisplatin. Of the responders, 77% are alive as compared to only 8% of the nonresponders. Maintenance of the responses by monthly combination chemotherapy remains a significant problem. Moreover, 83% and 70% of patients who received weekly Cisplatin as first-and third-line induction chemotherapy, respectively, had objective responses. Of the total 43 patients who received weekly Cisplatin as first-, second-, or third-line chemotherapy, 60% responded, including complete clinical responses in 14% and partial responses in 46%.

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