cis-3,4-Dichlorocyclobutene as a Versatile Synthon in Organic Synthesis. Rapid Entry into Complex Polycyclic Systems with Remarkably Stereospecific Reactions

✍ Scribed by K. C. Nicolaou; Juan A. Vega; Georgios Vassilikogiannakis

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 182 KB
• Volume: 40
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/1521-3773(20011203)40:23<4441::aid-anie4441>3.0.co;2-i

✦ Synopsis

The frequent natural occurrence and wide-ranging biological activities of cyclic polyether-type structures has stimulated considerable efforts directed toward their synthesis. Of particular interest are the aminoglycoside antibiotics represented by apramycin [2] and the marine neurotoxins represented by maitotoxin. [3] The former is of current interest by virtue of its RNA-binding properties, [2] whereas the latter constitutes a formidable synthetic challenge owing to its unprecedented molecular complexity and size. Functionalized polyether structures of type 1 (Scheme 1) embody Cl Cl