Reversal of doxorubicin resistance in br
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Pei-Jen Lou; Ping-Shan Lai; Ming-Jium Shieh; Alexander J. MacRobert; Kristian Be
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Article
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2006
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John Wiley and Sons
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French
⚖ 291 KB
## Abstract Multiple drug resistance (MDR) is a problem that seriously reduces the efficacy of many chemotherapy agents. One mechanism for MDR is increased acidification of endocytic vesicles and increased cytosol pH, so weak base chemotherapeutic agents, including doxorubicin, are trapped in endoc