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Circumvention of P-glycoprotein-mediated drug resistance in human leukaemic cells by non-immunosuppressive cyclosporin D analogue, SDZ PSC 833

โœ Scribed by XU-RONG JIANG; STEPHEN M. KELSEY; YU-LING Wn; ADRIAN C. NEWLAND


Book ID
114714117
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
1000 KB
Volume
90
Category
Article
ISSN
0007-1048

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๐Ÿ“œ SIMILAR VOLUMES


SDZ PSC 833, A non-immunosuppressive cyc
โœ Roland P. Keller; Hans J. Altermatt; Kees Nooter; Guenter Poschmann; Jean A. Lai ๐Ÿ“‚ Article ๐Ÿ“… 1992 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 637 KB

Cyclosporin A (CsA, Sandimmune) is known to reverse P-glycoprotein(P-gp I70)mediated multidrug resistance as efficiently as other prototype compounds of resistance modifiers. The immunosuppressive activity and nephrotoxicity of CsA, however, may limit its clinical use. PSC-833, a new cyclosporine, e