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Circulating Vα24+ Vβ11+ NKT Cell Numbers Are Decreased in a Wide Variety of Diseases That Are Characterized by Autoreactive Tissue Damage

✍ Scribed by Hans J.J. van der Vliet; B.Mary E. von Blomberg; Nobusuke Nishi; Martine Reijm; Alexandre E. Voskuyl; Ad A. van Bodegraven; Chris H. Polman; Thomas Rustemeyer; Paul Lips; Alfons J.M. van den Eertwegh; Giuseppe Giaccone; Rik J. Scheper; Herbert M. Pinedo

Book ID: 118768459
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 61 KB
Volume: 100
Category: Article
ISSN: 1090-2341
DOI: 10.1006/clim.2001.5060

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## Abstract Natural killer T (NKT) cells are CD1d‐restricted lymphoid cells and are characterized by an invariant T‐cell receptor, which in humans consists of a Vα24 chain paired with a Vβ11 chain. These cells are known for their rapid production of large amounts of cytokines (__e.g.__, IFN‐γ and I