Circulating Tumor Cells

✍ Scribed by Richard J. Cote, Ram H. Datar (eds.)

Publisher: Springer-Verlag New York
Year: 2016
Tongue: English
Leaves: 345
Series: Current Cancer Research
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

This volume provides the latest research on circulating tumor cells aimed for cancer researchers, scientists, and molecular oncologists. It presents the basic concepts behind circulating tumor cells (CTCs), metastatic biology, and potential applications as to how CTCs can be used in diagnostic biomarkers.

✦ Table of Contents

Front Matter....Pages i-xxiv
Front Matter....Pages 1-1
Significance of Studying Circulating Tumor Cells....Pages 3-15
Affinity-Based Enrichment of Circulating Tumor Cells....Pages 17-28
Size-Based and Non-Affinity Based Microfluidic Devices for Circulating Tumor Cell Enrichment and Characterization....Pages 29-45
Molecular Assays for the Detection and Molecular Characterization of CTCs....Pages 47-74
Cancer Stem Cells and Circulating Tumor Cells: Molecular Markers, Isolation Techniques, and Clinical Implications....Pages 75-97
Front Matter....Pages 99-99
Circulating Tumor Cells and Tumor Dormancy....Pages 101-120
Prevention of Conversion of Tumor Dormancy into Proliferative Metastases....Pages 121-137
Genesis of Circulating Tumor Cells Through Epithelial–Mesenchymal Transition as a Mechanism for Distant Dissemination....Pages 139-182
Front Matter....Pages 183-183
CTC Analysis: FISH, ISH, Array-CGH, and Other Molecular Assays....Pages 185-199
Genome-Wide Gene Copy Number Analysis of Circulating Tumor Cells....Pages 201-213
Perspectives on the Functional Characterization and In Vitro Maintenance of Circulating Tumor Cells....Pages 215-231
Prognostic Implications of CTC in Breast Cancer....Pages 233-254
Front Matter....Pages 255-255
CTC in Advanced Breast Cancer Prognosis, Monitoring, and Clinical Utility....Pages 257-270
Evolution of Metastatic Disease: The Need for Monitoring and Emerging Therapeutic Opportunities....Pages 271-292
CTCs for Biomarker and Companion Diagnostic Development....Pages 293-313
Perspectives on Clinical Applications of CTCs....Pages 315-323
Back Matter....Pages 325-333

✦ Subjects

Cancer Research

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