Circulating neprilysin clears brain amyloid
โ Scribed by Yinxing Liu; Christa Studzinski; Tina Beckett; M. Paul Murphy; Ronald L. Klein; Louis B. Hersh
- Book ID
- 116735632
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 831 KB
- Volume
- 45
- Category
- Article
- ISSN
- 1044-7431
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## Abstract A number of therapeutic strategies for treating Alzheimer's disease have focused on reducing amyloid burden in the brain. Among these approaches, the expression of amyloid ฮฒ peptide (Aฮฒ)โdegrading enzymes in the brain has been shown to be effective but to date not practical for treating
## Abstract Accumulation of the ฮฒโamyloid peptide (Aฮฒ) in the brain is a major pathological hallmark of Alzheimer's disease (AD), leading to synaptic dysfunction, neuronal death, and memory impairment. The levels of neprilysin, a major Aฮฒโdegrading enzyme, are decreased in AD brains and during agin