Circulating mediators of bone remodeling in psoriatic arthritis: implications for disordered osteoclastogenesis and bone erosion

Lack of requirement of osteopontin for i

Lack of requirement of osteopontin for inflammation, bone erosion, and cartilage damage in the K/BxN model of autoantibody-mediated arthritis

✍ Jonathan P. Jacobs; Allison R. Pettit; Mari L. Shinohara; Marianne Jansson; Harv 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 986 KB

## Abstract ## Objective Osteopontin (OPN) is a secreted glycoprotein involved in a range of physiologic processes, including inflammation, immunity mediated by Th1 cells, and bone remodeling. It is expressed in the joints of rheumatoid arthritis patients and has been the subject of conflicting re