✦ LIBER ✦

Circulating immune complexes and chemotherapy response in patients with head and neck cancer

✍ Scribed by Beverly A. Blazar; Dr. Marvin P. Fried; Marshall Strome; John R. Clark; Patricia Sereno; Susan Rodliff; David Caminear

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 467 KB
Volume: 11
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.2880110509

No coin nor oath required. For personal study only.

✦ Synopsis

An assay which could prospectively predict a response to chemotherapy prior to instituting therapy would be beneficial, especially for nonresponders. We evaluated at random a total of 50 patients with previously untreated stage 111 and IV head and neck squamous cell carcinoma for T-cell subsets and levels of circulating immune complexes (CIC). Of this group 23 patients had induction chemotherapy as their first modality of treatment. These patients received standard protocols of therapy consisting of cisplatin, 5-fluorouracil, methotrexate, and bleomycin. Of the laboratory measures assessed, only CIC correlated with clinical response to chemotherapy [no response (NR), partial response (PR), complete response (CR)] at the completion of the induction period (two to four cycles). Levels of CIC were determined by a polyethylene glycol (PEG) precipitation assay, and measured by spectrophotometry at 280 nm. In our population of all head and neck cancer patients, CIC were elevated (mean 2

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