Insulin-like growth factor-I (IGF-I) has mitogenic and antiapoptotic effects on breast cancer cells. Epidemiologic studies have shown that high plasma levels of IGF-I and low levels of IGF binding protein (BP)-3 are associated with increased risk of breast cancer in premenopausal women. The actions
Circulating concentrations of insulin-like growth factor I and risk of breast cancer
β Scribed by Susan E Hankinson; Walter C Willett; Graham A Colditz; David J Hunter; Dominique S Michaud; Bonnie Deroo; Bernard Rosner; Frank E Speizer; Michael Pollak
- Book ID
- 117310910
- Publisher
- The Lancet
- Year
- 1998
- Tongue
- English
- Weight
- 69 KB
- Volume
- 351
- Category
- Article
- ISSN
- 0140-6736
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## Abstract Increased levels of insulinβlike growth factor I (IGFβI) may directly stimulate breast cell proliferation and promote growth and survival of transformed cells. Higher levels of IGFβI have been associated with increased risk of premenopausal breast cancer but not postmenopausal breast ca
## Abstract Insulinβlike growth factor (IGF)βI, a mitogenic and antiβapoptotic peptide, has been implicated in the development of several cancers. We hypothesized that high circulating IGFβI concentrations may be associated with an increased risk of ovarian cancer. A caseβcontrol study was nested w