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Circulating concentrations of insulin-like growth factor I and risk of breast cancer

✍ Scribed by Susan E Hankinson; Walter C Willett; Graham A Colditz; David J Hunter; Dominique S Michaud; Bonnie Deroo; Bernard Rosner; Frank E Speizer; Michael Pollak


Book ID
117310910
Publisher
The Lancet
Year
1998
Tongue
English
Weight
69 KB
Volume
351
Category
Article
ISSN
0140-6736

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Insulin-like growth factor-I (IGF-I) has mitogenic and antiapoptotic effects on breast cancer cells. Epidemiologic studies have shown that high plasma levels of IGF-I and low levels of IGF binding protein (BP)-3 are associated with increased risk of breast cancer in premenopausal women. The actions

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