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Circulating COMP is decreased in pseudoachondroplasia and multiple epiphyseal dysplasia patients carrying COMP mutations

โœ Scribed by Mabuchi, Akihiko ;Momohara, Shigeki ;Ohashi, Hirofumi ;Takatori, Yoshio ;Haga, Nobuhiko ;Nishimura, Gen ;Ikegawa, Shiro


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
63 KB
Volume
129A
Category
Article
ISSN
0148-7299

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Pseudoachondroplasia (PSACH) and some forms of multiple epiphyseal dysplasia (MED) result from mutations in the gene encoding cartilage oligomeric matrix protein (COMP). COMP is a large pentameric glycoprotein found predominantly in the extracellular matrix of cartilage, tendon, and ligament. As a m