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Circular-Dichroism Studies on Artemisinin and Epiartemisinin and Their β-Cyclodextrin Complexes in Solution

✍ Scribed by Giancarlo Marconi; Sandra Monti; Francesco Manoli; Alessandra Degli Esposti; Andrea Guerrini

Publisher
John Wiley and Sons
Year
2004
Tongue
German
Weight
206 KB
Volume
87
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

The circular dichroism (CD) spectra of the powerful antimalarian active principle artemisinin (ART; 1) from Artemisia annua, and of epiartemisinin (EPI, 2), its C(7) epimer, were studied in solution in the presence and absence of β‐cyclodextrin (β‐cd). A significant inversion of sign in the region of the second electronic transition was detected. The rotational strengths were successfully calculated within the time‐dependent density functional theory (DFT), which enabled us to establish a correlation between the molecular recognition and the biological acitivities of the two isomers.

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