Circular dichroism studies of carbopeptoid-cyclodextrins

✍ Scribed by Alison A. Edwards; George W.J. Fleet; Ben A. Mayes; Stuart J. Hunter; George E. Tranter

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 1013 KB
• Volume: 17
• Category: Article
• ISSN: 0899-0042
• DOI: 10.1002/chir.20117

✦ Synopsis

A series of sugar amino acids, based on open chain sugars, have been oligomerised and cyclised. The resulting cyclic carbopeptoids have been examined for desirable properties such as host-guest chemistry (as in cyclodextrins) or self-assembling properties (e.g., peptide nanotubes). Initial studies of these systems, by circular dichroism and X-ray crystallography, have given valuable insight into their stability and properties. One of the four cyclic species studied was found to interact with ion/molecular probes.