Circadian variations of serum myoglobin levels in normal subjects and patients with polymyositis

✍ Scribed by Stefano Bombardieri; Aldo Clerico; Lucrezia Riente; Maria Grazia Del Chicca; Claudio Vitali

• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: English
• Weight: 483 KB
• Volume: 25
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780251205

✦ Synopsis

Abstract

Circadian variations in myoglobin levels were determined in 18 normal volunteers and in 10 patients with active polymyositis. In all the controls and in 9 of the 10 patients, serum myoglobin concentrations were highest at 9 AM, fell significantly during the day to reach a nadir between 6 and 12 PM, remained constant until midnight, and then rose again at 3 AM. The percent differences between the highest and lowest values ranged from 21–66%. This pattern was observed in both untreated patients and patients receiving 6‐methyl‐prednisolone, which was given either in a single dose at 8 AM or in divided doses (8 AM and 8 PM). These data demonstrate that the time of sample collection must be taken into account when myoglobin levels are used as a marker of muscle damage.