Circadian rhythm in toxic effects of cys
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Nathalie Martineau-Pivoteau; Francis Levi; Christine Rolhion; Fabrice Kwiatkowsk
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Article
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1996
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John Wiley and Sons
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French
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Cystemustine is a new nitrosourea with high anti-tumor activity and a short plasma half-life in mice. The influence of circadian dosing time upon its toxicities was first investigated in a total of 368 synchronized male B6DZFI mice. Late survival rate varied from 4% in mice receiving a single dose o