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Circadian rhythm of cytochrome P4502E1 and its effect on disposition kinetics of chlorzoxazone in rats

โœ Scribed by Phisit Khemawoot; Kousuke Nishino; Junko Ishizaki; Koichi Yokogawa; Ken-ichi Miyamoto

Book ID
113587045
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
244 KB
Volume
574
Category
Article
ISSN
0014-2999

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โœ Reza Mehvar; Ragini Vuppugalla ๐Ÿ“‚ Article ๐Ÿ“… 2006 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 178 KB

The steady-state disposition of chlorzoxazone (CZX) and its hydroxylated metabolite 6-hydroxychlorzoxazone (HCZX) was determined in a single-pass isolated perfused rat liver (IPRL) model using constant CZX concentrations of 10-200 microM. The concentrations of CZX, HCZX, and/or HCZX glucuronide in t